Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.64 |
| ▸ | TP53 | P04637 | 9/20 | 0.64 |
| ▸ | RAB9A | P51151 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | NPC1 | O15118 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | TSHR | P16473 | 5/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070025 | 0.99 | SMN1; SMN2 (0.62) | SMN1; SMN2TP53RAB9AMAPTNPC1 | |
| Bromide SCHEMBL7479450 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2TP53RAB9AMAPTNPC1 | |
| Bromide SCHEMBL7475518 | 0.78 | MAPT (0.56) | SMN1; SMN2TP53RAB9AMAPTNPC1 | |
| SCHEMBL7479395 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2TP53RAB9AMAPTNPC1 | |
| SCHEMBL11136884 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53RAB9AMAPTNPC1 | |
| SCHEMBL5553141 | 0.77 | SMN1; SMN2 (0.97) | SMN1; SMN2TP53RAB9AMAPTNPC1 | |
| Dimethylamine SCHEMBL8559714 | 0.73 | SMN1; SMN2 (0.87) | SMN1; SMN2TP53RAB9AMAPTNPC1 | |
| Bromide SCHEMBL11359084 | 0.69 | RAB9A (0.68) | SMN1; SMN2TP53RAB9AMAPTNPC1 | |
| SCHEMBL11353979 | 0.69 | SMN1; SMN2 (0.60) | SMN1; SMN2TP53RAB9AMAPTNPC1 | |
| SCHEMBL8596815 | 0.69 | HSD17B10 (0.47) | SMN1; SMN2TP53RAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843681-B1 | HETEROCYCLE-FUSED THIAZOLE DERIVATIVES | YUNGJIN PHARMACEUTICAL CO LTD (KR) | 2002-03-06 | — | — | EP | disclosed |
| US-6043373-A | ANTIULCER AGENT | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-03-28 | — | — | US | disclosed |