Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 7/20 | 0.75 |
| ▸ | PKN2 | Q16513 | 7/20 | 0.75 |
| ▸ | PLK4 | O00444 | 1/20 | 0.75 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.75 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.75 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.75 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.75 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.75 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.75 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.75 |
| ▸ | PIM1 | P11309 | 1/20 | 0.75 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.75 |
| ▸ | PRKACA | P17612 | 1/20 | 0.75 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.75 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.75 |
| ▸ | CLK2 | P49760 | 1/20 | 0.75 |
| ▸ | GSK3A | P49840 | 1/20 | 0.75 |
| ▸ | PRKX | P51817 | 1/20 | 0.75 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.75 |
| ▸ | STK3 | Q13188 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474958 | 0.87 | PKN1 (0.77) | PKN1PKN2PLK4MAPK13DYRK3 | |
| SCHEMBL6809991 | 0.86 | PKN1 (1.00) | PKN1PKN2PLK4MAPK13DYRK3 | |
| SCHEMBL6805685 | 0.85 | PKN1 (0.77) | PKN1PKN2PLK4MAPK13DYRK3 | |
| SCHEMBL505315 | 0.84 | DHODH (0.82) | PKN1PKN2PLK4MAPK13DYRK3 | |
| SCHEMBL25220279 | 0.82 | PKN1 (1.00) | PKN1PKN2PLK4MAPK13DYRK3 | |
| SCHEMBL30440938 | 0.82 | PKN1 (1.00) | PKN1PKN2PLK4MAPK13DYRK3 | |
| SCHEMBL6810422 | 0.79 | PKN1 (0.76) | PKN1PKN2PLK4MAPK13DYRK3 | |
| SCHEMBL1298432 | 0.76 | DHODH (0.94) | PARP1DHODH | |
| SCHEMBL30440661 | 0.76 | PKN1 (0.66) | PKN1PKN2PLK4MAPK13DYRK3 | |
| SCHEMBL25217212 | 0.76 | PKN1 (0.66) | PKN1PKN2PLK4MAPK13DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |