Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 12/20 | 0.82 |
| ▸ | PARP1 | P09874 | 6/20 | 0.78 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.78 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.73 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.73 |
| ▸ | PLK4 | O00444 | 1/20 | 0.73 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.73 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.73 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.73 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.73 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.73 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.73 |
| ▸ | PIM1 | P11309 | 1/20 | 0.73 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.73 |
| ▸ | PRKACA | P17612 | 1/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.73 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.73 |
| ▸ | CLK2 | P49760 | 1/20 | 0.73 |
| ▸ | GSK3A | P49840 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474958 | 0.97 | PKN1 (0.77) | DHODHPARP1PARP2PKN1PKN2 | |
| SCHEMBL505661 | 0.90 | DHODH (1.00) | DHODHPARP1 | |
| SCHEMBL10212017 | 0.87 | PARP1 (0.97) | DHODHPARP1PARP2 | |
| SCHEMBL1298432 | 0.87 | DHODH (0.94) | DHODHPARP1 | |
| SCHEMBL10211812 | 0.86 | DHODH (0.82) | DHODHPARP1PARP2 | |
| SCHEMBL10211815 | 0.85 | PARP1 (0.77) | DHODHPARP1PARP2 | |
| SCHEMBL10212033 | 0.85 | DHODH (0.84) | DHODHPARP1PARP2PKN1PKN2 | |
| SCHEMBL7479538 | 0.84 | PKN1 (0.75) | DHODHPARP1PARP2PKN1PKN2 | |
| SCHEMBL6809991 | 0.84 | PKN1 (1.00) | DHODHPARP1PARP2PKN1PKN2 | |
| SCHEMBL505262 | 0.84 | DHODH (0.74) | DHODHPARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414328-B1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO SA (CH) | 2021-05-26 | — | — | EP | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| US-9006454-B2 | Dihydroorotate dehydrogenase inhibitors | MERCK SERONO S.A. (CH) | 2015-04-14 | — | — | US | disclosed |
| EP-2414328-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Merck Serono S.A. (CH) | 2012-02-08 | — | — | EP | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2012-02-02 | — | — | US | disclosed |
| WO-2010115736-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010115736-A2 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028959-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, FH, DPYD | DHODH 1/4885PARP1 1086/4885PARP2 1017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.