Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 4/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CBX7 | O95931 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7969182 | 0.99 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BMAP3K7LPAR1 | |
| Hydrochloric Acid SCHEMBL7337572 | 0.94 | AVPR2 (0.43) | AVPR2AVPR1AAVPR1BMAP3K7LPAR1 | |
| SCHEMBL7478471 | 0.92 | MAP3K7 (0.36) | AVPR2AVPR1AAVPR1BMAP3K7LPAR1 | |
| SCHEMBL7966890 | 0.91 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BMAP3K7ALDH1A1 | |
| SCHEMBL7338979 | 0.91 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BMAP3K7MEN1 | |
| Hydrochloric Acid SCHEMBL7964351 | 0.91 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAP3K7ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7346786 | 0.90 | AVPR2 (0.44) | AVPR2AVPR1AAVPR1BMAP3K7LPAR1 | |
| SCHEMBL7339127 | 0.90 | AVPR2 (0.44) | AVPR2AVPR1AAVPR1BMAP3K7LPAR1 | |
| SCHEMBL7336265 | 0.89 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BMAP3K7 | |
| SCHEMBL7336166 | 0.89 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |