Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 3/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7964351 | 0.99 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAPTALDH1A1 | |
| SCHEMBL7342762 | 0.94 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BMAPTALDH1A1 | |
| SCHEMBL7966903 | 0.92 | MAPT (0.36) | AVPR2AVPR1AAVPR1BMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7482761 | 0.92 | MAPT (0.35) | AVPR2AVPR1AAVPR1BMAPTALDH1A1 | |
| SCHEMBL7479643 | 0.91 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL7969182 | 0.91 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BALDH1A1CYP1A2 | |
| SCHEMBL7966842 | 0.89 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7337572 | 0.88 | AVPR2 (0.43) | AVPR2AVPR1AAVPR1BALDH1A1MAP3K7 | |
| SCHEMBL7338979 | 0.87 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BALDH1A1CYP1A2 | |
| SCHEMBL7966897 | 0.87 | ALDH1A1 (0.34) | MAPTALDH1A1AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |