Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479944 | 1.00 | ALDH1A1 (0.41) | ALDH1A1HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL7479135 | 0.88 | KDM4E (0.41) | ALDH1A1HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL7479131 | 0.88 | KDM4E (0.41) | ALDH1A1HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL7478412 | 0.85 | ALDH1A1 (0.39) | ALDH1A1HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL7477737 | 0.85 | ALDH1A1 (0.39) | ALDH1A1HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL7478409 | 0.85 | ALDH1A1 (0.39) | ALDH1A1HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL7477734 | 0.85 | ALDH1A1 (0.39) | ALDH1A1HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL7475545 | 0.84 | KDM4E (0.42) | ALDH1A1HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL7478732 | 0.84 | KDM4E (0.39) | ALDH1A1HSD17B10KDM4ETSHRLMNA | |
| SCHEMBL7478727 | 0.84 | KDM4E (0.39) | ALDH1A1HSD17B10KDM4ETSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |