Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 12/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6737207 | 0.88 | CYP11B1 (0.53) | CYP11B1CYP11B2GSK3BCA1CA2 | |
| SCHEMBL6737213 | 0.88 | CYP11B1 (0.53) | CYP11B1CYP11B2GSK3BCA1CA2 | |
| Dimethylformamide SCHEMBL7479987 | 0.85 | CYP11B1 (0.46) | CYP11B1CYP11B2GSK3BCA1CA2 | |
| SCHEMBL23839943 | 0.78 | CYP11B1 (0.48) | CYP11B1CYP11B2GSK3BCA1CA2 | |
| SCHEMBL11013190 | 0.76 | CYP11B1 (0.47) | CYP11B1CYP11B2GSK3BCA1CA2 | |
| SCHEMBL11009980 | 0.76 | CYP11B1 (0.47) | CYP11B1CYP11B2GSK3BCA1CA2 | |
| SCHEMBL23832223 | 0.76 | CYP11B1 (0.47) | CYP11B1CYP11B2GSK3BCA1CA2 | |
| SCHEMBL16110488 | 0.72 | CYP2C9 (0.50) | CYP11B1CYP11B2GSK3BALDH1A1MAPT | |
| SCHEMBL16110489 | 0.72 | CYP2C9 (0.50) | CYP11B1CYP11B2GSK3BALDH1A1MAPT | |
| SCHEMBL30144859 | 0.72 | CYP2C9 (0.50) | CYP11B1CYP11B2GSK3BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192157-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |