Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.42 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404268 | 0.94 | CHEK2 (0.49) | GPR119USP30ALDH1A1PIK3CDPDE4B | |
| SCHEMBL7356060 | 0.94 | GPR119 (0.54) | GPR119ALDH1A1PDE4BHRH3CHEK2 | |
| SCHEMBL27143206 | 0.91 | GPR119 (0.49) | GPR119USP30ALDH1A1PIK3CDPDE4B | |
| SCHEMBL27150382 | 0.91 | GPR119 (0.49) | GPR119USP30ALDH1A1PIK3CDPDE4B | |
| SCHEMBL7399784 | 0.91 | CA12 (0.46) | GPR119USP30ALDH1A1PDE4BSTS | |
| SCHEMBL7477254 | 0.88 | PDE4B (0.51) | GPR119USP30ALDH1A1PIK3CDPDE4B | |
| SCHEMBL27108934 | 0.86 | GPR119 (0.53) | GPR119USP30ALDH1A1PIK3CDPDE4B | |
| SCHEMBL25206434 | 0.84 | GPR119 (0.56) | GPR119ALDH1A1PDE4BHRH3CHEK2 | |
| SCHEMBL30612802 | 0.84 | GPR119 (0.56) | GPR119ALDH1A1PDE4BHRH3CHEK2 | |
| SCHEMBL5548878 | 0.84 | GPR119 (0.55) | GPR119USP30ALDH1A1PIK3CDPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714299-B1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-04-24 | — | — | EP | disclosed |
| US-5665719-A | Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists | MERCK & CO., INC. (US) | 1997-09-09 | — | — | US | disclosed |