SCHEMBL7480264

SCHEMBL7480264

Oc1ccc2c(c1)CN(Nc1ccncc1)CC2

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DRD1 P21728 10/20 0.43
DRD2 P14416 9/20 0.43
DRD5 P21918 9/20 0.43
DRD3 P35462 8/20 0.43
DRD4 P21917 6/20 0.42
ESR1 P03372 3/20 0.42
ESR2 Q92731 3/20 0.42
CYP19A1 P11511 3/20 0.40
GPR142 Q7Z601 1/20 0.39
CYP11B2 P19099 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7481558 0.88 CYP19A1 (0.41) DRD1DRD2DRD5DRD3ESR1
Bromide SCHEMBL7481771 0.87 CYP19A1 (0.40) DRD1DRD2DRD5DRD3DRD4
SCHEMBL7483332 0.86 DRD1 (0.48) DRD1DRD2DRD5DRD3DRD4
Bromide SCHEMBL7484858 0.85 DRD1 (0.47) DRD1DRD2DRD5DRD3DRD4
SCHEMBL7477903 0.80 EED (0.54) DRD1DRD2DRD5DRD3DRD4
SCHEMBL7485133 0.80 DRD1 (0.48) DRD1DRD2DRD5DRD3DRD4
SCHEMBL7489287 0.80 MEN1 (0.34) DRD1DRD2DRD5DRD3DRD4
Bromide SCHEMBL7484876 0.79 CYP17A1 (0.34) DRD1DRD2DRD5DRD3DRD4
SCHEMBL7489812 0.78 ESR2 (0.42) DRD1DRD2DRD5DRD3DRD4
SCHEMBL7481508 0.77 MEN1 (0.36) DRD1DRD2DRD5DRD3DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP claimed
CN-1242012-A N- (pyridylamino) isoindolines and related compounds HOECHST MARION ROUSSEL INC (US) 2000-01-19 CN claimed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP claimed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO claimed
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed