Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13163159 | 0.84 | HPGD (0.58) | HPGDALDH1A1MAPK1SMN1; SMN2MEN1 | |
| SCHEMBL31301322 | 0.82 | MEN1 (0.51) | HPGDKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL13972667 | 0.81 | HPGD (0.49) | HPGDKDM4EALDH1A1MAPK1POLB | |
| SCHEMBL31301265 | 0.80 | HPGD (0.55) | HPGDKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL28023692 | 0.79 | PTGS2 (0.46) | HPGDKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL23020285 | 0.78 | HPGD (0.50) | HPGDKDM4EALDH1A1MAPK1POLB | |
| SCHEMBL6605121 | 0.78 | TSHR (0.51) | HPGDKDM4EALDH1A1POLBGAA | |
| SCHEMBL2062239 | 0.77 | HPGD (0.46) | HPGDKDM4EALDH1A1MAPK1POLB | |
| SCHEMBL14691000 | 0.76 | KCNA5 (0.46) | HPGDKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL436252 | 0.76 | KMT2A (0.44) | HPGDKDM4EMAPK1GLAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436919-B1 | LOCAL ANESTHETICS THAT HAVE LONGER DURATION OF ACTION WHILE REDUCING UNDESIRED SIDE EFFECTS | THERAVANCE INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1216242-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1216243-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| US-6355637-B1 | QUINAZOLONES FOR LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001025235-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |
| WO-2001025234-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |