Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | FAP | Q12884 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049947 | 0.86 | ADORA1 (0.44) | ADORA1KDM4EKEAP1ALDH1A1MAPT | |
| SCHEMBL6050008 | 0.81 | ADORA1 (0.41) | ADORA1KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL5839237 | 0.81 | ADORA1 (0.41) | ADORA1KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL7860310 | 0.81 | KDM4E (0.41) | ADORA1KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL7483750 | 0.80 | ADORA1 (0.40) | ADORA1KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL7480468 | 0.73 | ADORA1 (0.45) | ADORA1KDM4EKEAP1ALDH1A1MAPT | |
| SCHEMBL6316724 | 0.70 | ADORA1 (0.38) | ADORA1KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL7094861 | 0.70 | ADORA1 (0.40) | ADORA1KDM4EALDH1A1MAPTRAD52 | |
| SCHEMBL7094863 | 0.70 | ADORA1 (0.40) | ADORA1KDM4EALDH1A1MAPTRAD52 | |
| SCHEMBL6316671 | 0.69 | GRM6 (0.36) | ADORA1KDM4EALOX15TSHRSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214060-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017516-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2001-03-15 | — | — | WO | disclosed |