Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483750 | 0.84 | ADORA1 (0.40) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL7860317 | 0.79 | ADORA1 (0.42) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL27077058 | 0.74 | MAPT (0.56) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL27077062 | 0.74 | MAPT (0.56) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL5837716 | 0.73 | GRM6 (0.38) | ADORA1MAPTKDM4EGAALMNA | |
| SCHEMBL7480457 | 0.73 | ADORA1 (0.41) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL6049947 | 0.72 | ADORA1 (0.44) | ADORA1MAPTALDH1A1KDM4ERAD52 | |
| SCHEMBL25377457 | 0.67 | PREP (0.69) | MAPTPREPGAAMEN1KMT2A | |
| SCHEMBL25379533 | 0.67 | PREP (0.55) | MAPTALDH1A1PREPGAAMEN1 | |
| SCHEMBL25378171 | 0.67 | PREP (0.55) | MAPTALDH1A1PREPGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214060-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017516-A2 | METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2001-03-15 | — | — | WO | disclosed |