Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11179375 | 0.91 | TDP1 (0.67) | DRD4MEN1KMT2ATDP1KDM4E | |
| SCHEMBL893830 | 0.91 | TDP1 (0.67) | DRD4MEN1KMT2ATDP1KDM4E | |
| SCHEMBL6660880 | 0.82 | DRD4 (0.56) | DRD4MEN1KMT2ATDP1KDM4E | |
| SCHEMBL21657446 | 0.82 | KDM4E (0.59) | DRD4MEN1KMT2ATDP1KDM4E | |
| SCHEMBL21657638 | 0.82 | DRD4 (0.56) | DRD4MEN1KMT2ATDP1KDM4E | |
| SCHEMBL4406338 | 0.80 | DRD4 (0.58) | DRD4MEN1KMT2ATDP1KDM4E | |
| SCHEMBL176947 | 0.79 | MEN1 (0.61) | DRD4MEN1KMT2ATDP1MAOA | |
| Hydrochloric Acid SCHEMBL29484777 | 0.79 | DRD4 (0.56) | DRD4MEN1KMT2ATDP1KDM4E | |
| SCHEMBL14318340 | 0.78 | MEN1 (0.73) | DRD4MEN1KMT2ATDP1MAOA | |
| SCHEMBL21657637 | 0.78 | KDM4E (0.59) | DRD4MEN1KMT2ATDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436919-B1 | LOCAL ANESTHETICS THAT HAVE LONGER DURATION OF ACTION WHILE REDUCING UNDESIRED SIDE EFFECTS | THERAVANCE INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1216243-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001025234-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |