Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821928 | 0.88 | ALDH1A1 (0.49) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6096918 | 0.82 | ALDH1A1 (0.58) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL22854493 | 0.82 | ALDH1A1 (0.57) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3816839 | 0.80 | KDM4E (0.57) | ALDH1A1SMN1; SMN2MAPTPOLBRAB9A | |
| SCHEMBL3828558 | 0.79 | TSHR (0.83) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7475492 | 0.76 | TSHR (0.55) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL874882 | 0.76 | TSHR (0.58) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL22854475 | 0.76 | KDM4E (0.44) | TSHRKMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL22854483 | 0.74 | ALDH1A1 (0.53) | TSHRALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL11008746 | 0.74 | CASR (0.72) | TSHRMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436919-B1 | LOCAL ANESTHETICS THAT HAVE LONGER DURATION OF ACTION WHILE REDUCING UNDESIRED SIDE EFFECTS | THERAVANCE INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1216243-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001025234-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |