SCHEMBL7483733

SCHEMBL7483733

O=C(O)C1Cc2ccc(O)cc2CN1Cc1cccc(Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.44
OPRM1 P35372 1/20 0.42
OPRD1 P41143 1/20 0.42
OPRK1 P41145 1/20 0.42
S1PR1 P21453 1/20 0.42
S1PR5 Q9H228 1/20 0.42
MMP8 P22894 2/20 0.41
MMP3 P08254 1/20 0.41
SIGMAR1 Q99720 1/20 0.41
HDAC8 Q9BY41 1/20 0.40
PPARD Q03181 2/20 0.40
PPARA Q07869 2/20 0.40
PPARG P37231 1/20 0.40
CLK1 P49759 1/20 0.40
DYRK1A Q13627 1/20 0.40
GRM6 O15303 1/20 0.39
POLB P06746 1/20 0.39
ATM Q13315 1/20 0.39
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7483726 1.00 CYP19A1 (0.44) CYP19A1OPRM1OPRD1OPRK1S1PR1
SCHEMBL27496734 0.92 CYP19A1 (0.51) CYP19A1OPRM1OPRD1OPRK1MMP8
SCHEMBL7539116 0.89 POLB (0.48) MMP8MMP3SIGMAR1PPARDPPARA
SCHEMBL7537137 0.89 POLB (0.48) MMP8MMP3SIGMAR1PPARDPPARA
SCHEMBL7537140 0.89 POLB (0.48) MMP8MMP3SIGMAR1PPARDPPARA
SCHEMBL7482104 0.86 HDAC8 (0.54) OPRM1OPRD1OPRK1S1PR1S1PR5
SCHEMBL7482114 0.86 HDAC8 (0.54) OPRM1OPRD1OPRK1S1PR1S1PR5
SCHEMBL28803636 0.80 CLK1 (0.43) S1PR1S1PR5SIGMAR1CLK1DYRK1A
SCHEMBL4478400 0.79 CYP19A1 (0.53) CYP19A1OPRM1MMP8MMP3SIGMAR1
SCHEMBL7478005 0.78 ACE (0.49) CYP19A1MMP8MMP3GRM6POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1045844-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2002-08-21 EP claimed
EP-1045844-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2000-10-25 EP claimed
WO-1999028314-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1999-06-10 WO claimed
EP-1045844-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2002-08-21 EP disclosed
EP-1045844-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2000-10-25 EP disclosed
US-5932590-A PEPTIDOMIMETIC IMIDAZOLYL-CONTAINING 1,2,3,4-TETRAHYDRO-QUINOLINES OR AN ANALOGOUS 3-BENZAZEPINES; ANTICARCINOGENIC AND-PROLIFERATIVE AGENTS; POLYCYSTIC KIDNEY DISEASE; RESTENOSIS PREVENTION; HEPATITIS; RETINAL VASCULARZATION MERCK & CO., INC. (US) 1999-08-03 US disclosed
WO-1999028314-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1999-06-10 WO disclosed