SCHEMBL7478005

SCHEMBL7478005

O=C(O)[C@@H]1Cc2ccccc2CN1Cc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ACE P12821 5/20 0.49
GRM6 O15303 1/20 0.49
CYP19A1 P11511 1/20 0.48
TDP1 Q9NUW8 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
MMP8 P22894 3/20 0.47
MMP3 P08254 2/20 0.47
MMP13 P45452 1/20 0.47
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
ADORA2A P29274 1/20 0.46
POLB P06746 2/20 0.45
CHEK1 O14757 1/20 0.45
JAK2 O60674 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29870443 1.00 ACE (0.49) ACEGRM6CYP19A1TDP1L3MBTL1
SCHEMBL8336724 1.00 ACE (0.49) ACEGRM6CYP19A1TDP1L3MBTL1
SCHEMBL8342131 0.91 MMP8 (0.58) ACECYP19A1TDP1L3MBTL1MMP8
SCHEMBL8342126 0.91 MMP8 (0.58) ACECYP19A1TDP1L3MBTL1MMP8
SCHEMBL7537137 0.89 POLB (0.48) TDP1L3MBTL1MMP8MMP3MMP13
SCHEMBL7537140 0.89 POLB (0.48) TDP1L3MBTL1MMP8MMP3MMP13
SCHEMBL7539116 0.89 POLB (0.48) TDP1L3MBTL1MMP8MMP3MMP13
SCHEMBL6920302 0.87 HDAC8 (0.53) TDP1L3MBTL1MMP3POLBCHEK1
SCHEMBL7534383 0.87 ALDH1A1 (0.50) ACEALDH1A1LMNAPOLB
SCHEMBL7534380 0.87 ALDH1A1 (0.50) ACEALDH1A1LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015103527-A1 MODULATORS OF REV-ERB THE SCRIPPS RESEARCH INSTITUTE (US) 2015-07-09 WO disclosed
EP-1045844-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2002-08-21 EP disclosed
EP-1045844-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2000-10-25 EP disclosed
US-5932590-A PEPTIDOMIMETIC IMIDAZOLYL-CONTAINING 1,2,3,4-TETRAHYDRO-QUINOLINES OR AN ANALOGOUS 3-BENZAZEPINES; ANTICARCINOGENIC AND-PROLIFERATIVE AGENTS; POLYCYSTIC KIDNEY DISEASE; RESTENOSIS PREVENTION; HEPATITIS; RETINAL VASCULARZATION MERCK & CO., INC. (US) 1999-08-03 US disclosed
WO-1999028314-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1999-06-10 WO disclosed