Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.47 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477942 | 0.90 | CRHR1 (0.49) | CRHR1CNR1 | |
| SCHEMBL7472211 | 0.86 | CRHR1 (0.48) | CRHR1CNR1LIMK1LIMK2 | |
| SCHEMBL6204021 | 0.85 | CRHR1 (0.56) | CRHR1CNR1 | |
| SCHEMBL7477440 | 0.84 | CRHR1 (0.44) | CRHR1CNR1 | |
| SCHEMBL7479299 | 0.84 | CRHR1 (0.65) | CRHR1CNR1 | |
| SCHEMBL5412657 | 0.84 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL5409704 | 0.81 | CRHR1 (0.71) | CRHR1CNR1 | |
| SCHEMBL7480028 | 0.80 | CRHR1 (0.47) | CRHR1CNR1 | |
| SCHEMBL5409778 | 0.79 | CRHR1 (0.64) | CRHR1CNR1 | |
| SCHEMBL5410139 | 0.77 | CRHR1 (0.71) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |