Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485167 | 1.00 | MAPT (0.48) | MAPTNPC1RAB9AMAPK1KDM4E | |
| SCHEMBL6991145 | 0.88 | MAPT (0.50) | MAPTNPC1RAB9AMAPK1KDM4E | |
| SCHEMBL6991136 | 0.88 | MAPT (0.50) | MAPTNPC1RAB9AMAPK1KDM4E | |
| SCHEMBL7482142 | 0.80 | MAPT (0.49) | MAPTNPC1RAB9AMAPK1KDM4E | |
| SCHEMBL7482156 | 0.80 | MAPT (0.49) | MAPTNPC1RAB9AMAPK1KDM4E | |
| SCHEMBL519257 | 0.79 | MAPT (0.56) | MAPTNPC1RAB9AMAPK1KDM4E | |
| SCHEMBL7493335 | 0.77 | MAPT (0.46) | MAPTNPC1RAB9AMAPK1KDM4E | |
| SCHEMBL7493347 | 0.77 | MAPT (0.46) | MAPTNPC1RAB9AMAPK1KDM4E | |
| SCHEMBL7490755 | 0.76 | MAPT (0.54) | MAPTNPC1RAB9AMAPK1KDM4E | |
| SCHEMBL7490754 | 0.76 | MAPT (0.54) | MAPTNPC1RAB9AMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0712402-B1 | HYDROISOQUINOLINE DERIVATIVES | SMITHKLINE BEECHAM SPA (IT) | 2002-04-10 | — | — | EP | disclosed |
| US-5731322-A | ADMINISTERING AS ANALGESICS OR IMMUNOMODULATING AND/OR CARDIOVASCULAR AGENTS | SMITHKLINE BEECHAM S.P.A. (IT) | 1998-03-24 | — | — | US | disclosed |
| EP-0712402-A1 | HYDROISOQUINOLINE DERIVATIVES | Smithkline Beecham S.p.A. (IT) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004734-A1 | HYDROISOQUINOLINE DERIVATIVES | SMITHKLINE BEECHAM FARMACEUTICI S.P.A. (IT) | 1995-02-16 | — | — | WO | disclosed |