Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.63 |
| ▸ | CDK2 | P24941 | 2/20 | 0.63 |
| ▸ | CLK2 | P49760 | 2/20 | 0.63 |
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.63 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.63 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.63 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.63 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.63 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.63 |
| ▸ | CSF1R | P07333 | 2/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8477008 | 0.91 | GSK3B (0.53) | PIM1CDK2CLK2GSK3BCAMK2B | |
| SCHEMBL8479083 | 0.89 | GSK3B (0.56) | PIM1CDK2CLK2GSK3BCAMK2B | |
| SCHEMBL8475930 | 0.89 | GSK3B (0.54) | PIM1CDK2CLK2GSK3BCAMK2B | |
| SCHEMBL8479190 | 0.89 | CYP2C9 (0.73) | PIM1CDK2CLK2GSK3BCAMK2B | |
| SCHEMBL8479093 | 0.87 | CDK2 (0.52) | PIM1CDK2CLK2GSK3BCAMK2B | |
| Formic Acid SCHEMBL8479075 | 0.85 | CYP2C9 (0.68) | PIM1CDK2CLK2GSK3BCAMK2B | |
| SCHEMBL8476391 | 0.82 | CYP2C9 (0.53) | PIM1CDK2CLK2GSK3BCAMK2B | |
| SCHEMBL8481285 | 0.82 | PIM1 (0.55) | PIM1CDK2CLK2GSK3BCAMK2B | |
| SCHEMBL8481050 | 0.81 | PIM1 (0.76) | PIM1CDK2CLK2GSK3BCAMK2B | |
| SCHEMBL8480429 | 0.80 | CYP2C9 (0.62) | PIM1CDK2CLK2GSK3BCAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011677-A4 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-1011677-A1 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | Bristol-Myers Squibb Company (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5972961-A | ANTIISCHEMIC AGENTS; ANTICONVULSANTS; HEADACHES; SEXUAL DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1999009983-A1 | 4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |