Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | GAA | P10253 | 1/20 | 0.79 |
| ▸ | HPGD | P15428 | 1/20 | 0.79 |
| ▸ | RAB9A | P51151 | 1/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NOS1 | P29475 | 4/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372553 | 0.89 | ROCK2 (1.00) | ROCK2MAPTROCK1KDM4EMEN1 | |
| SCHEMBL117208 | 0.89 | ROCK2 (1.00) | ROCK2MAPTROCK1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL3873262 | 0.87 | ROCK2 (0.96) | ROCK2MAPTROCK1KDM4EMEN1 | |
| Water SCHEMBL28188426 | 0.87 | ROCK2 (0.96) | ROCK2MAPTROCK1KDM4EMEN1 | |
| SCHEMBL5412320 | 0.80 | ROCK1 (0.57) | ROCK2MAPTROCK1KDM4EMEN1 | |
| SCHEMBL5412316 | 0.80 | ROCK1 (0.57) | ROCK2MAPTROCK1KDM4EMEN1 | |
| SCHEMBL5407640 | 0.80 | ROCK1 (0.57) | ROCK2MAPTROCK1KDM4EMEN1 | |
| SCHEMBL5823182 | 0.76 | CYP3A4 (0.55) | ROCK2MAPTROCK1KDM4EMEN1 | |
| SCHEMBL14514388 | 0.75 | ROCK2 (0.64) | ROCK2MAPTROCK1KDM4EMEN1 | |
| SCHEMBL1716937 | 0.75 | ROCK2 (0.64) | ROCK2MAPTROCK1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218384-A4 | TETRACYCLIC BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2002-11-20 | — | — | EP | disclosed |
| EP-1218384-A1 | TETRACYCLIC BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001023392-A1 | TETRACYCLIC BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-04-05 | — | — | WO | disclosed |