Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 8/20 | 0.54 |
| ▸ | GRK5 | P34947 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23541040 | 0.89 | HDAC6 (0.52) | LMNAFYNGRK5HDAC6APOBEC3A | |
| SCHEMBL23540645 | 0.87 | HDAC6 (0.48) | LMNAFYNGRK5HDAC6BRD4 | |
| SCHEMBL23540360 | 0.82 | HDAC6 (0.46) | LMNAFYNHDAC6APOBEC3AAPOBEC3G | |
| SCHEMBL20556098 | 0.81 | LMNA (0.62) | LMNAFYNKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL23540398 | 0.78 | HDAC6 (0.50) | LMNAFYNGRK5HDAC6BRD4 | |
| SCHEMBL23562539 | 0.78 | HDAC6 (0.54) | LMNAFYNGRK5HDAC6APOBEC3A | |
| SCHEMBL23541010 | 0.76 | HDAC6 (0.41) | LMNAFYNGRK5HDAC6BRD4 | |
| SCHEMBL23728468 | 0.75 | LMNA (0.66) | LMNAAPOBEC3AAPOBEC3GKDM4EPOLB | |
| SCHEMBL23562856 | 0.74 | HDAC6 (0.51) | LMNAFYNGRK5HDAC6APOBEC3A | |
| SCHEMBL17664418 | 0.74 | PLA2G10 (0.61) | FYNGRK5PLA2G10PLA2G2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237891-A1 | HETEROCYCLIC DIHYDROPYRIMIDINES AS POTASSIUM CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001040231-A1 | HETEROCYCLIC DIHYDROPYRIMIDINES AS POTASSIUM CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-06-07 | — | — | WO | claimed |