Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485641 | 0.85 | TSHR (0.35) | TSHRSMN1; SMN2LMNAALDH1A1GAA | |
| SCHEMBL5098738 | 0.84 | CACNA1B (0.39) | TSHRSMN1; SMN2KDM4E | |
| SCHEMBL6594878 | 0.82 | CTSK (0.41) | TSHRSMN1; SMN2GAAUSP2KDM4E | |
| SCHEMBL5098717 | 0.80 | TSHR (0.33) | TSHRSMN1; SMN2 | |
| SCHEMBL6630415 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL4685652 | 0.78 | CTSK (0.45) | SMN1; SMN2LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL6594875 | 0.68 | CTSK (0.40) | TSHRSMN1; SMN2USP2KDM4EHTT | |
| SCHEMBL5098815 | 0.67 | CTSK (0.47) | — | |
| SCHEMBL5105868 | 0.67 | MEN1 (0.44) | ALDH1A1HPGDMAPT | |
| SCHEMBL5092594 | 0.66 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |