Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.57 |
| ▸ | GART | P22102 | 12/20 | 0.55 |
| ▸ | FOLR1 | P15328 | 10/20 | 0.46 |
| ▸ | FOLR2 | P14207 | 3/20 | 0.46 |
| ▸ | ATIC | P31939 | 2/20 | 0.46 |
| ▸ | SLC46A1 | Q96NT5 | 7/20 | 0.46 |
| ▸ | SLC19A1 | P41440 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14403392 | 0.97 | DHFR (0.59) | DHFRGARTFOLR1FOLR2ATIC | |
| SCHEMBL9381786 | 0.97 | DHFR (0.59) | DHFRGARTFOLR1FOLR2ATIC | |
| SCHEMBL9383067 | 0.97 | DHFR (0.59) | DHFRGARTFOLR1FOLR2ATIC | |
| SCHEMBL9380609 | 0.97 | DHFR (0.59) | DHFRGARTFOLR1FOLR2ATIC | |
| SCHEMBL9381796 | 0.97 | DHFR (0.59) | DHFRGARTFOLR1FOLR2ATIC | |
| SCHEMBL7482065 | 0.95 | DHFR (0.54) | DHFRGARTFOLR1FOLR2ATIC | |
| SCHEMBL7485670 | 0.95 | DHFR (0.52) | DHFRGARTFOLR1FOLR2ATIC | |
| SCHEMBL7488019 | 0.94 | DHFR (0.57) | DHFRGARTFOLR1FOLR2ATIC | |
| SCHEMBL7487723 | 0.93 | DHFR (0.51) | DHFRGARTFOLR1FOLR2ATIC | |
| SCHEMBL9381055 | 0.92 | DHFR (0.55) | DHFRGARTFOLR1FOLR2ATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0761668-B1 | Non-classical antifolates | UNIV PRINCETON (US) | 2002-01-30 | — | — | EP | claimed |
| EP-0761668-A2 | Non-classical antifolates | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1997-03-12 | — | — | EP | claimed |
| EP-0761668-B1 | Non-classical antifolates | UNIV PRINCETON (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-0761668-A2 | Non-classical antifolates | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1997-03-12 | — | — | EP | disclosed |