Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 10/20 | 0.68 |
| ▸ | KDR | P35968 | 8/20 | 0.68 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | MET | P08581 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492087 | 0.89 | PDGFRA (0.77) | PDGFRAKDRFGFR2METKIT | |
| SCHEMBL8552489 | 0.86 | PDGFRA (0.65) | PDGFRAKDRFGFR2PDGFRBMET | |
| SCHEMBL7486400 | 0.86 | FGFR2 (0.84) | PDGFRAKDRFGFR2PDGFRB | |
| SCHEMBL5825958 | 0.83 | PDGFRA (0.62) | PDGFRAKDRFGFR2PDGFRBMET | |
| SCHEMBL3501883 | 0.82 | KDR (0.63) | PDGFRAKDRFGFR2PDGFRBMET | |
| SCHEMBL5824417 | 0.82 | PDGFRA (0.63) | PDGFRAKDRFGFR2PDGFRBMET | |
| SCHEMBL7489910 | 0.82 | FGFR2 (0.76) | PDGFRAKDRFGFR2PDGFRBMET | |
| SCHEMBL7489440 | 0.82 | PDGFRA (0.76) | PDGFRAKDRFGFR2METKIT | |
| SCHEMBL5204152 | 0.82 | PDGFRA (0.75) | PDGFRAKDRFGFR2KITAXL | |
| SCHEMBL27082958 | 0.81 | PDGFRA (0.62) | PDGFRAKDRFGFR2PDGFRBMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0860433-B1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BREWERY (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-6143764-A | ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2000-11-07 | — | — | US | disclosed |