Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.63 |
| ▸ | AURKA | O14965 | 4/20 | 0.63 |
| ▸ | MET | P08581 | 4/20 | 0.63 |
| ▸ | TEK | Q02763 | 4/20 | 0.63 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 2/20 | 0.54 |
| ▸ | RET | P07949 | 7/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31218163 | 0.86 | KDR (0.71) | KDRAURKBAURKAMETTEK | |
| SCHEMBL12411989 | 0.86 | KDR (0.65) | KDRAURKBAURKAMETTEK | |
| SCHEMBL1890626 | 0.85 | KDR (0.70) | KDRAURKBAURKAMETTEK | |
| SCHEMBL12411987 | 0.84 | AXL (0.70) | KDRAURKBAURKAMETTEK | |
| SCHEMBL12411988 | 0.83 | KDR (0.55) | KDRAURKBAURKAMETTEK | |
| SCHEMBL1889883 | 0.83 | KDR (0.56) | KDRAURKBAURKAMETTEK | |
| SCHEMBL12411990 | 0.83 | KDR (0.53) | KDRAURKBAURKAMETTEK | |
| SCHEMBL7486131 | 0.82 | PDGFRA (0.68) | KDRAURKBAURKAMETTEK | |
| SCHEMBL29186593 | 0.82 | KDR (0.69) | KDRAURKBAURKAMETTEK | |
| SCHEMBL2173091 | 0.82 | KDR (0.64) | KDRAURKBAURKAMETTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | GNG2, GCG, FRG1 | KDR 2687/4885AURKB 1909/4885AURKA 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.