SCHEMBL7486242

SCHEMBL7486242

Cc1oc(-c2ccccc2)nc1CCC(O)c1ccc(CCCC2OC(=O)NC2=O)cc1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.49
PPARA Q07869 14/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7494333 0.95 PPARG (0.47) PPARGPPARA
SCHEMBL7487592 0.90 PPARG (0.47) PPARGPPARA
SCHEMBL7485799 0.88 PPARG (0.53) PPARGPPARA
SCHEMBL7489773 0.88 PPARG (0.53) PPARGPPARA
SCHEMBL7488887 0.85 PPARG (0.50) PPARGPPARA
SCHEMBL7486812 0.83 PPARG (0.48) PPARGPPARA
SCHEMBL7486254 0.83 PPARG (0.49) PPARGPPARA
SCHEMBL7162959 0.82 PPARG (0.59) PPARGPPARA
SCHEMBL7162075 0.82 PPARG (0.58) PPARGPPARA
SCHEMBL8794339 0.81 FFAR1 (0.60) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0643050-B1 Oxazolidinedione derivatives and their use as hypoglycemic agent TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-04-10 EP disclosed
US-5614544-A HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-03-25 US disclosed
EP-0643050-A1 Oxazolidinedione derivatives and their use as hypoglycemic agent Takeda Chemical Industries, Ltd. (JP) 1995-03-15 EP disclosed