SCHEMBL7494333

SCHEMBL7494333

Cc1oc(-c2ccccc2)nc1CCC(O)c1ccc(CCC2OC(=O)NC2=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.47
PPARA Q07869 16/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7486242 0.95 PPARG (0.49) PPARGPPARA
SCHEMBL7487592 0.92 PPARG (0.47) PPARGPPARA
SCHEMBL7164855 0.84 PPARG (0.62) PPARGPPARA
SCHEMBL7483358 0.83 FFAR1 (0.46) PPARGPPARA
SCHEMBL7494345 0.82 PPARG (0.47) PPARGPPARA
SCHEMBL7489773 0.82 PPARG (0.53) PPARGPPARA
SCHEMBL7485799 0.82 PPARG (0.53) PPARGPPARA
SCHEMBL8795234 0.81 FFAR1 (0.62) PPARGPPARA
SCHEMBL7488887 0.81 PPARG (0.50) PPARGPPARA
SCHEMBL8840367 0.80 PPARG (0.51) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0643050-B1 Oxazolidinedione derivatives and their use as hypoglycemic agent TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-04-10 EP disclosed
US-5614544-A HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-03-25 US disclosed
EP-0643050-A1 Oxazolidinedione derivatives and their use as hypoglycemic agent Takeda Chemical Industries, Ltd. (JP) 1995-03-15 EP disclosed