Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4114860 | 0.92 | EIF2AK2 (0.54) | EIF2AK2GSK3BMAPK14KDM4EPIK3CA | |
| SCHEMBL6590583 | 0.89 | GSK3B (0.48) | EIF2AK2GSK3BMAPK14PIK3CAPIK3CG | |
| SCHEMBL7485716 | 0.84 | MAPK14 (0.63) | EIF2AK2GSK3BMAPK14MAPK13MAPK12 | |
| SCHEMBL6604144 | 0.81 | CDK2 (0.55) | EIF2AK2GSK3BEGFRCDK4CDK2 | |
| SCHEMBL7805607 | 0.79 | MAPK14 (0.49) | MAPK14KDM4E | |
| SCHEMBL1387838 | 0.78 | MAPK14 (0.54) | MAPK14KDM4EMAPK13MAPK12MAPK11 | |
| SCHEMBL7482928 | 0.78 | MAPK14 (0.54) | EIF2AK2GSK3BMAPK14MAPK13MAPK12 | |
| SCHEMBL7486651 | 0.78 | MAPK14 (0.56) | EIF2AK2GSK3BMAPK14MAPK13MAPK12 | |
| SCHEMBL7500317 | 0.77 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL9648933 | 0.76 | KDM4E (0.82) | GSK3BMAPK14KDM4EMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037639-A4 | COMPOUNDS OF HETEROARYL SUBSTITUTED IMIDAZOLE, THEIR PHARMACEUTICAL COMPOSITIONS AND USES | SMITHKLINE BEECHAM CORP (US) | 2002-04-17 | — | — | EP | claimed |
| EP-1037639-A1 | COMPOUNDS OF HETEROARYL SUBSTITUTED IMIDAZOLE, THEIR PHARMACEUTICAL COMPOSITIONS AND USES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-27 | — | — | EP | claimed |
| WO-1999032121-A1 | COMPOUNDS OF HETEROARYL SUBSTITUTED IMIDAZOLE, THEIR PHARMACEUTICAL COMPOSITIONS AND USES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-01 | — | — | WO | claimed |
| EP-1037639-A4 | COMPOUNDS OF HETEROARYL SUBSTITUTED IMIDAZOLE, THEIR PHARMACEUTICAL COMPOSITIONS AND USES | SMITHKLINE BEECHAM CORP (US) | 2002-04-17 | — | — | EP | disclosed |
| EP-1037639-A1 | COMPOUNDS OF HETEROARYL SUBSTITUTED IMIDAZOLE, THEIR PHARMACEUTICAL COMPOSITIONS AND USES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999032121-A1 | COMPOUNDS OF HETEROARYL SUBSTITUTED IMIDAZOLE, THEIR PHARMACEUTICAL COMPOSITIONS AND USES | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |