Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.57 |
| ▸ | RAF1 | P04049 | 3/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | BRD2 | P25440 | 2/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482928 | 0.92 | MAPK14 (0.54) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL7486651 | 0.91 | MAPK14 (0.56) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL8113482 | 0.88 | MAPK14 (0.58) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL8112671 | 0.88 | PIK3CG (0.61) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL8119524 | 0.88 | CSNK1A1 (0.69) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL7988334 | 0.86 | CSNK1A1 (0.69) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL8118041 | 0.86 | CSNK1A1 (0.53) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL8119978 | 0.84 | CSNK1A1 (0.56) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL8549518 | 0.83 | MAPK14 (0.62) | MAPK14MAPK13MAPK9MAPK12MAPK11 | |
| SCHEMBL5772631 | 0.82 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0961618-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0961618-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998025619-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-06-18 | — | — | WO | disclosed |