Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 18/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29755511 | 0.90 | KIF11 (0.50) | KIF11DNMT1 | |
| SCHEMBL7486608 | 0.90 | KIF11 (0.42) | KIF11CYP1A2CYP2D6 | |
| SCHEMBL20553873 | 0.89 | KIF11 (0.41) | KIF11CYP1A2CYP2D6DNMT1 | |
| SCHEMBL1899105 | 0.85 | KIF11 (0.44) | KIF11CYP1A2CYP2D6 | |
| SCHEMBL232514 | 0.83 | KIF11 (0.42) | KIF11CYP1A2CYP2D6DNMT1 | |
| SCHEMBL14343479 | 0.82 | KIF11 (0.49) | KIF11DNMT1 | |
| SCHEMBL9064015 | 0.81 | KIF11 (0.36) | KIF11CYP1A2CYP2D6 | |
| SCHEMBL6745551 | 0.80 | KMT2A (0.44) | KIF11CYP1A2CYP2D6 | |
| SCHEMBL5674471 | 0.79 | CYP2C19 (0.39) | KIF11CYP1A2CYP2D6 | |
| SCHEMBL28378741 | 0.79 | CYP1A2 (0.44) | KIF11CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0935601-A4 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | DU PONT PHARM CO (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1012151-A1 | HETEROCYCLYL-SUBSTITUTED RING-FUSED PYRIDINES AND PYRIMIDINES AS CORTICOTROPIN RELEASING HORMONE (CRH) ANTAGONISTS, USEFUL FOR TREATING CNS AND STRESS-RELATED DISORDERS | Dupont Pharmaceuticals Company (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-0935601-A2 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | Du Pont Pharmaceuticals Company (US) | 1999-08-18 | — | — | EP | disclosed |
| WO-1999011643-A1 | HETEROCYCLYL-SUBSTITUTED RING-FUSED PYRIDINES AND PYRIMIDINES AS CORTICOTROPIN RELEASING HORMONE (CRH) ANTAGONISTS, USEFUL FOR TREATING CNS AND STRESS-RELATED DISORDERS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-03-11 | — | — | WO | disclosed |
| WO-1997035539-A2 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | DU PONT PHARMACEUTICALS COMPANY (US) | 1997-10-02 | — | — | WO | disclosed |