Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486961 | 1.00 | AOC3 (0.52) | AOC3CHRNB2CHRNA4NOS2SLC6A4 | |
| SCHEMBL7491436 | 0.86 | AOC3 (0.50) | AOC3SLC6A4SLC6A2SLC6A3IDO1 | |
| SCHEMBL27606230 | 0.84 | AOC3 (0.49) | AOC3SLC6A4SLC6A2SLC6A3IDO1 | |
| SCHEMBL10858664 | 0.84 | AOC3 (0.51) | AOC3CHRNB2CHRNA4NOS2IDO1 | |
| SCHEMBL10860685 | 0.83 | AOC3 (0.67) | AOC3CHRNB2CHRNA4NOS2SLC6A4 | |
| Hydrochloric Acid SCHEMBL31332740 | 0.82 | AOC3 (0.65) | AOC3CHRNB2CHRNA4NOS2SLC6A4 | |
| SCHEMBL10862916 | 0.81 | AOC3 (0.49) | AOC3CHRNB2CHRNA4NOS2SLC6A4 | |
| SCHEMBL7490605 | 0.80 | AOC3 (0.45) | AOC3SLC6A4SLC6A2SLC6A3IDO1 | |
| SCHEMBL10727832 | 0.79 | CHRNB2 (0.48) | AOC3CHRNB2CHRNA4NOS2IDO1 | |
| SCHEMBL10859856 | 0.79 | AOC3 (0.47) | AOC3CHRNB2CHRNA4NOS2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825189-B1 | 1,4-BENZODIOXIN DERIVATIVES | NISSHIN PHARMA INC (JP) | 2002-01-02 | — | — | EP | disclosed |
| US-6130243-A | PROPHYLACTIC OR THERAPEUTIC AGENT FOR DIABETES, HYPERGLYCEMIA AND OBESITY IN MAMMALS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 2000-10-10 | — | — | US | disclosed |
| EP-0825189-A1 | 1,4-BENZODIOXIN DERIVATIVES | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |