Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545209 | 0.82 | KDR (0.59) | KDRMAPTLMNANTRK1CDK19 | |
| SCHEMBL5594890 | 0.82 | KDR (0.59) | KDRMAPTLMNANTRK1CDK19 | |
| SCHEMBL5594672 | 0.80 | KDR (0.69) | KDRMAPTNTRK1CDK19MEN1 | |
| SCHEMBL23447441 | 0.76 | MAPT (0.71) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7491660 | 0.76 | CHRNA7 (0.54) | KDRMAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL7493381 | 0.75 | KDR (0.62) | KDRMAPTNTRK1CDK19MEN1 | |
| SCHEMBL5604191 | 0.74 | CXCR1 (0.58) | MAPTLMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5594895 | 0.74 | CHRNA7 (0.61) | KDRMAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL5595253 | 0.74 | CHRNA7 (0.61) | KDRMAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL1463419 | 0.71 | NTRK1 (0.81) | KDRMAPTNTRK1CDK19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |