Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594895 | 1.00 | CHRNA7 (0.61) | CHRNA7KMT2AMEN1MAPTTP53 | |
| SCHEMBL7491660 | 0.93 | CHRNA7 (0.54) | CHRNA7KMT2AMEN1MAPTTP53 | |
| SCHEMBL29776952 | 0.82 | CHRNA7 (0.76) | CHRNA7KMT2AMEN1MAPTTP53 | |
| SCHEMBL20472469 | 0.82 | CHRNA7 (0.76) | CHRNA7KMT2AMEN1MAPTTP53 | |
| SCHEMBL5594890 | 0.81 | KDR (0.59) | KMT2AMEN1MAPTTP53TRPV1 | |
| SCHEMBL7545209 | 0.81 | KDR (0.59) | KMT2AMEN1MAPTTP53TRPV1 | |
| SCHEMBL6763103 | 0.81 | CYP3A4 (0.61) | CHRNA7KMT2AMEN1MAPTTP53 | |
| SCHEMBL5595358 | 0.78 | TRPV1 (0.61) | CHRNA7KMT2AMEN1MAPTTP53 | |
| SCHEMBL5594738 | 0.77 | CHRNA7 (0.66) | CHRNA7KMT2AMEN1MAPTTP53 | |
| SCHEMBL7551270 | 0.77 | CHRNA7 (0.69) | CHRNA7KMT2AMEN1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809492-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0809492-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025157-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-22 | — | — | WO | disclosed |