Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 19/20 | 0.63 |
| ▸ | ITGA2B | P08514 | 17/20 | 0.63 |
| ▸ | ITGAV | P06756 | 7/20 | 0.62 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.51 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8457211 | 0.82 | ITGB3 (0.53) | ITGB3ITGA2BITGAV | |
| SCHEMBL6869118 | 0.82 | ITGB3 (0.59) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7490912 | 0.81 | ITGB3 (0.91) | ITGB3ITGA2BITGAV | |
| SCHEMBL7490276 | 0.79 | ITGB3 (0.59) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7490266 | 0.79 | ITGB3 (0.59) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7484493 | 0.77 | ITGB3 (0.60) | ITGB3ITGA2BMMP2MMP9 | |
| SCHEMBL7039327 | 0.77 | ITGB3 (0.72) | ITGB3ITGA2BITGAV | |
| SCHEMBL7108722 | 0.77 | ITGB3 (0.72) | ITGB3ITGA2BITGAV | |
| SCHEMBL7490090 | 0.77 | ITGB3 (0.62) | ITGB3ITGA2BITGAVMMP2MMP9 | |
| SCHEMBL8802408 | 0.77 | ITGB3 (0.62) | ITGB3ITGA2BITGAVMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760658-B1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | claimed |
| EP-0760658-A4 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 1997-09-17 | — | — | EP | claimed |
| EP-0760658-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO. INC. (US) | 1997-03-12 | — | — | EP | claimed |
| WO-1995032710-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO., INC. (US) | 1995-12-07 | — | — | WO | claimed |
| EP-0760658-B1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-0760658-A4 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0760658-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO. INC. (US) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032710-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO., INC. (US) | 1995-12-07 | — | — | WO | disclosed |