SCHEMBL7487382

SCHEMBL7487382

CC(=O)NCC1CN(c2ccc(N3CCN(C=O)CC3)c(F)c2)C(=O)O1

nearest known ligand 0.78

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.78
MAOA P21397 5/20 0.78
PTGS1 P23219 2/20 0.78
SDHA P31040 2/20 0.78
LMNA P02545 1/20 0.78
CALML3 P27482 1/20 0.78
F10 P00742 7/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10151556 0.93 MAOB (0.78) MAOBMAOAPTGS1SDHALMNA
SCHEMBL7529741 0.93 MAOB (0.66) MAOBMAOAPTGS1SDHALMNA
SCHEMBL7529735 0.93 MAOB (0.66) MAOBMAOAPTGS1SDHALMNA
SCHEMBL6498605 0.90 MAOB (0.74) MAOBMAOAPTGS1SDHALMNA
SCHEMBL7821447 0.90 MAOA (0.70) MAOBMAOAPTGS1SDHALMNA
SCHEMBL7821443 0.90 MAOA (0.70) MAOBMAOAPTGS1SDHALMNA
SCHEMBL1956748 0.90 MAOB (0.82) MAOBMAOAPTGS1SDHALMNA
SCHEMBL1953314 0.90 MAOB (0.82) MAOBMAOAPTGS1SDHALMNA
SCHEMBL1954721 0.90 MAOB (0.82) MAOBMAOAPTGS1SDHALMNA
SCHEMBL18410772 0.89 MAOA (0.82) MAOBMAOAPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640077-B1 OXAZOLIDINONES CONTAINING A SUBSTITUTED DIAZINE MOIETY AND THEIR USE AS ANTIMICROBIALS UPJOHN CO (US) 2002-06-26 EP claimed
EP-0640077-B1 OXAZOLIDINONES CONTAINING A SUBSTITUTED DIAZINE MOIETY AND THEIR USE AS ANTIMICROBIALS UPJOHN CO (US) 2002-06-26 EP disclosed
US-5547950-A FOR TREATING DRUG RESISTANT STAPHYLOCOCCUS AND STREPTOCOCCUS INFECTIONS THE UPJOHN COMPANY (US) 1996-08-20 US disclosed
EP-0640077-A1 OXAZOLIDINONES CONTAINING A SUBSTITUTED DIAZINE MOIETY AND THEIR USE AS ANTIMICROBIALS PHARMACIA & UPJOHN COMPANY (US) 1995-03-01 EP disclosed
WO-1993023384-A1 OXAZOLIDINONES CONTAINING A SUBSTITUTED DIAZINE MOIETY AND THEIR USE AS ANTIMICROBIALS THE UPJOHN COMPANY (US) 1993-11-25 WO disclosed