Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988536 | 0.89 | KDM4E (0.57) | HRH3HRH1KDM4ETP53DRD3 | |
| SCHEMBL3206275 | 0.85 | CYP2D6 (0.58) | HRH3HRH1KDM4ETP53DRD3 | |
| SCHEMBL4233204 | 0.83 | DRD2 (0.70) | HRH3HRH1KDM4ETP53DRD3 | |
| SCHEMBL1714405 | 0.81 | HRH3 (0.74) | HRH3HRH1DRD3KCNH2DRD2 | |
| SCHEMBL3196892 | 0.81 | POLB (0.52) | HRH3HRH1KDM4ETP53DRD3 | |
| SCHEMBL1714712 | 0.81 | HRH3 (0.77) | HRH3HRH1DRD3KCNH2DRD2 | |
| SCHEMBL18396586 | 0.81 | HRH3 (0.52) | HRH3HRH1KDM4ETP53DRD3 | |
| SCHEMBL6135057 | 0.80 | HRH3 (0.57) | HRH3HRH1KDM4ETP53DRD3 | |
| SCHEMBL6135382 | 0.80 | HRH3 (0.57) | HRH3HRH1KDM4ETP53DRD3 | |
| SCHEMBL6135083 | 0.80 | HRH3 (0.57) | HRH3HRH1KDM4ETP53DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | disclosed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | disclosed |
| EP-1023287-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020622-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 1999-04-29 | — | — | WO | disclosed |