Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490771 | 0.97 | ADORA1 (0.52) | ADORA1CYP2D6CYP2C9MAPK1KDM4E | |
| SCHEMBL7485492 | 0.96 | ADORA1 (0.51) | ADORA1CYP2D6CYP2C9MAPK1EGFR | |
| SCHEMBL7485481 | 0.94 | ADORA1 (0.52) | ADORA1MAPK1EGFRIGF1RTP53 | |
| SCHEMBL7488376 | 0.91 | ADORA1 (0.51) | ADORA1MAPK1EGFRIGF1RAKT1 | |
| SCHEMBL7487498 | 0.88 | ADORA1 (0.53) | ADORA1MAPK1EGFRIGF1RAKT1 | |
| Hydrochloric Acid SCHEMBL7541956 | 0.87 | ADORA1 (0.52) | ADORA1MAPK1EGFRIGF1RCHRM1 | |
| SCHEMBL7495433 | 0.86 | ADORA1 (0.50) | ADORA1MAPK1IGF1RAKT1 | |
| SCHEMBL7496245 | 0.83 | ADORA1 (0.48) | ADORA1MAPK1EGFRIGF1RAKT1 | |
| SCHEMBL7668541 | 0.82 | ADORA1 (0.53) | ADORA1MAPK1EGFRIGF1RAKT1 | |
| SCHEMBL7487132 | 0.82 | ADORA1 (0.52) | ADORA1MAPK1IGF1RAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925299-B1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-09-25 | — | — | EP | disclosed |
| US-6124456-A | Pyrazolopyridine compound and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-26 | — | — | US | disclosed |