Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487498 | 0.89 | ADORA1 (0.53) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| Hydrochloric Acid SCHEMBL7541956 | 0.88 | ADORA1 (0.52) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7488376 | 0.86 | ADORA1 (0.51) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7668541 | 0.86 | ADORA1 (0.53) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7487132 | 0.85 | ADORA1 (0.52) | ADORA1IGF1RMAPK1AKT1 | |
| SCHEMBL7663464 | 0.85 | ADORA1 (0.53) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7485481 | 0.85 | ADORA1 (0.52) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7486447 | 0.84 | NSD3 (0.52) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7495433 | 0.83 | ADORA1 (0.50) | ADORA1IGF1RMAPK1AKT1PDE3A | |
| SCHEMBL7488103 | 0.83 | ADORA1 (0.52) | ADORA1IGF1RMAPK1AKT1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925299-B1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-09-25 | — | — | EP | disclosed |
| US-6124456-A | Pyrazolopyridine compound and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-26 | — | — | US | disclosed |