Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.38 |
| ▸ | TET3 | O43151 | 2/20 | 0.38 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.34 |
| ▸ | FABP7 | O15540 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365673 | 0.86 | HTT (0.59) | HTTMEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL975279 | 0.77 | HTT (0.52) | HTTFABP7TSHR | |
| SCHEMBL23004700 | 0.76 | HTT (0.47) | HTTMEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL2690771 | 0.75 | HTT (0.50) | HTTMEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL10339411 | 0.72 | SMN1; SMN2 (0.54) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL305092 | 0.72 | SMN1; SMN2 (0.48) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL17132189 | 0.72 | SMN1; SMN2 (0.48) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL17132190 | 0.72 | SMN1; SMN2 (0.48) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL974718 | 0.72 | HTT (0.50) | HTTSMN1; SMN2FABP7MEN1ALDH1A1 | |
| SCHEMBL15282112 | 0.71 | SMN1; SMN2 (0.46) | SMN1; SMN2TET2TET3TET1OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | disclosed |
| EP-0535042-A1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS. | FISONS PLC (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000276-A2 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1992-01-09 | — | — | WO | disclosed |