Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11147008 | 0.88 | CNR1 (0.60) | ALDH1A1KMT2AOPRM1OPRD1L3MBTL1 | |
| SCHEMBL2960085 | 0.87 | ALDH1A1 (0.57) | ALDH1A1KMT2AOPRM1OPRD1L3MBTL1 | |
| SCHEMBL2088176 | 0.84 | KMT2A (0.56) | ALDH1A1KMT2AOPRM1OPRD1HSD17B10 | |
| SCHEMBL3924702 | 0.82 | ALDH1A1 (0.52) | ALDH1A1KMT2AOPRM1OPRD1L3MBTL1 | |
| SCHEMBL3927688 | 0.80 | KMT2A (0.58) | ALDH1A1KMT2AOPRM1OPRD1TDP1 | |
| SCHEMBL13977996 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KMT2AOPRM1OPRD1L3MBTL1 | |
| SCHEMBL11148885 | 0.78 | KMT2A (0.56) | ALDH1A1KMT2AOPRM1OPRD1TDP1 | |
| SCHEMBL9592081 | 0.78 | POLB (0.55) | ALDH1A1KMT2AL3MBTL1TDP1POLB | |
| SCHEMBL13018868 | 0.77 | POLB (0.53) | ALDH1A1KMT2AL3MBTL1TDP1POLB | |
| SCHEMBL16000808 | 0.76 | KMT2A (0.54) | ALDH1A1KMT2AOPRM1OPRD1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242396-A1 | NEW P2X 7 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF INFLAMMATORY, IMMUNE OR CARDIOVASCULAR DISEASES | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001044213-A1 | NEW P2X7 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF INFLAMMATORY, IMMUNE OR CARDIOVASCULAR DISEASES | ASTRAZENECA AB (SE) | 2001-06-21 | — | — | WO | disclosed |