Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 11/20 | 0.57 |
| ▸ | CXCR1 | P25024 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3704458 | 0.87 | CXCR2 (0.73) | CXCR2CXCR1RAB9ANPC1MEN1 | |
| SCHEMBL3715237 | 0.85 | KMT2A (0.68) | CXCR2CXCR1RAB9ANPC1MEN1 | |
| SCHEMBL7488390 | 0.80 | CXCR2 (0.53) | CXCR2CXCR1RAB9ANPC1MEN1 | |
| SCHEMBL24421980 | 0.80 | CXCR1 (0.46) | CXCR2CXCR1RAB9ANPC1MEN1 | |
| SCHEMBL7492930 | 0.76 | CXCR2 (0.72) | CXCR2CXCR1MEN1KMT2AHTT | |
| SCHEMBL7487837 | 0.73 | CXCR2 (1.00) | CXCR2CXCR1RAB9ANPC1MEN1 | |
| SCHEMBL5594974 | 0.72 | KMT2A (0.61) | CXCR2CXCR1RAB9ANPC1MEN1 | |
| SCHEMBL5595051 | 0.71 | HTT (0.52) | CXCR2CXCR1RAB9ANPC1MEN1 | |
| SCHEMBL8052698 | 0.71 | KMT2A (0.69) | RAB9ANPC1MEN1KMT2AHTT | |
| SCHEMBL3710377 | 0.70 | CXCR2 (0.75) | CXCR2CXCR1RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |