Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 9/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | DDX3X | O00571 | 1/20 | 0.41 |
| ▸ | F11 | P03951 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5605208 | 0.84 | RAB9A (0.58) | CXCR2CXCR1RAB9AHTTALDH1A1 | |
| SCHEMBL3704458 | 0.83 | CXCR2 (0.73) | CXCR2CXCR1RAB9AHTTIDH1 | |
| SCHEMBL7488394 | 0.80 | CXCR2 (0.57) | CXCR2CXCR1RAB9AHTTALDH1A1 | |
| SCHEMBL7492930 | 0.78 | CXCR2 (0.72) | CXCR2CXCR1HTTIDH1MEN1 | |
| SCHEMBL24421980 | 0.72 | CXCR1 (0.46) | CXCR2CXCR1RAB9AHTTALDH1A1 | |
| SCHEMBL7487837 | 0.70 | CXCR2 (1.00) | CXCR2CXCR1RAB9AHTTALDH1A1 | |
| SCHEMBL7897789 | 0.70 | CXCR1 (0.64) | CXCR2CXCR1RAB9AHTTALDH1A1 | |
| SCHEMBL5832789 | 0.69 | NPC1 (0.57) | RAB9AHTTALDH1A1NPC1MEN1 | |
| SCHEMBL7254811 | 0.69 | RAB9A (0.71) | RAB9AHTTALDH1A1NPC1MEN1 | |
| SCHEMBL6924667 | 0.69 | CXCR1 (0.73) | CXCR2CXCR1RAB9AHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |