Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 10/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | RAD52 | P43351 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | OXTR | P30559 | 1/20 | 0.68 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | HTR7 | P34969 | 2/20 | 0.67 |
| ▸ | EGFR | P00533 | 7/20 | 0.66 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.63 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.63 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6407779 | 0.90 | KMT2A (0.82) | PRMT5KMT2AMEN1RAD52MAPT | |
| SCHEMBL7489301 | 0.86 | HTR7 (0.68) | PRMT5KMT2AMEN1RAD52MAPT | |
| SCHEMBL8320590 | 0.85 | PRMT5 (0.81) | PRMT5KMT2AMEN1RAD52MAPT | |
| SCHEMBL6779743 | 0.82 | KMT2A (0.68) | PRMT5KMT2AMEN1RAD52MAPT | |
| SCHEMBL30274356 | 0.82 | HTR7 (0.70) | PRMT5HTR7EGFRHTR2AHTR2C | |
| SCHEMBL538174 | 0.81 | HTR7 (0.76) | PRMT5KMT2AMEN1RAD52MAPT | |
| SCHEMBL6782129 | 0.80 | HTR7 (0.82) | PRMT5KMT2AMEN1RAD52MAPT | |
| SCHEMBL6088731 | 0.79 | HTR7 (0.78) | PRMT5KMT2ARAD52MAPTMAPK1 | |
| SCHEMBL997957 | 0.78 | HTR7 (0.73) | PRMT5HTR7EGFRHTR2AHTR2C | |
| SCHEMBL2725785 | 0.78 | HTR2C (0.73) | PRMT5KMT2AMEN1RAD52MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912567-B1 | CARBOLINE DERIVATIVES | ICOS CORP (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6306870-B1 | PHOSPHODIESTERASE ENZYME INHIBITORS, CARDIOVASCULAR DISORDERS AND SEXUAL DISORDERS | ICOS CORPORATION | 2001-10-23 | — | — | US | disclosed |
| US-6117881-A | POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE | ICOS CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| US-6043252-A | A POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE (CGMP-SPECIFIC PDE); TREATING CARDIOVASCULAR DISORDERS AND ERECTILE DYSFUNCTION | ICOS CORPORATION (US) | 2000-03-28 | — | — | US | disclosed |