Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7528602 | 0.96 | SIGMAR1 (0.53) | SIGMAR1GRM2HTR1A | |
| SCHEMBL7468890 | 0.91 | SIGMAR1 (0.52) | SIGMAR1GRM2 | |
| SCHEMBL7470276 | 0.91 | SIGMAR1 (0.52) | SIGMAR1GRM2 | |
| SCHEMBL9676204 | 0.90 | GRM2 (0.57) | SIGMAR1GRM2HTR1A | |
| SCHEMBL7529808 | 0.89 | GRM2 (0.50) | SIGMAR1GRM2HTR1A | |
| SCHEMBL7487787 | 0.89 | SIGMAR1 (0.50) | SIGMAR1GRM2HTR1A | |
| Hydrochloric Acid SCHEMBL9679291 | 0.89 | GRM2 (0.56) | SIGMAR1GRM2HTR1A | |
| SCHEMBL7481896 | 0.89 | GRM2 (0.58) | SIGMAR1GRM2HTR1A | |
| SCHEMBL7473692 | 0.88 | SIGMAR1 (0.66) | SIGMAR1 | |
| SCHEMBL7484241 | 0.87 | SIGMAR1 (0.59) | SIGMAR1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763535-B1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GMBH (DE) | 2002-11-27 | — | — | EP | claimed |
| EP-0763535-A1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | claimed |
| EP-0763535-B1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GMBH (DE) | 2002-11-27 | — | — | EP | disclosed |
| EP-0763535-A1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |