SCHEMBL7489473

SCHEMBL7489473

COc1ccc(CC2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)cc1

nearest known ligand 0.64

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 5/20 0.64
PTGIR P43119 4/20 0.64
PTGER1 P34995 1/20 0.64
PTGER3 P43115 1/20 0.61
RAB9A P51151 3/20 0.38
L3MBTL1 Q9Y468 3/20 0.37
NPC1 O15118 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
ALDH1A1 P00352 3/20 0.36
MAPT P10636 3/20 0.36
LMNA P02545 2/20 0.36
TSHR P16473 1/20 0.36
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
S1PR1 P21453 1/20 0.36
NR1H4 Q96RI1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7480950 0.91 PTGIR (0.65) PTGER4PTGIRPTGER1PTGER3RAB9A
SCHEMBL7990542 0.90 PTGIR (0.76) PTGER4PTGIRPTGER1PTGER3RAB9A
SCHEMBL7949957 0.89 PTGIR (0.73) PTGER4PTGIRPTGER1PTGER3TDP1
SCHEMBL7479094 0.89 PTGIR (0.73) PTGER4PTGIRPTGER1PTGER3TDP1
SCHEMBL9006885 0.89 PTGIR (0.73) PTGER4PTGIRPTGER1PTGER3TDP1
SCHEMBL7961761 0.88 PTGIR (0.61) PTGER4PTGIRPTGER1PTGER3RAB9A
SCHEMBL8548332 0.88 PTGIR (0.66) PTGER4PTGIRPTGER1PTGER3ALDH1A1
SCHEMBL7489401 0.87 PTGER4 (0.69) PTGER4PTGIRPTGER1PTGER3RAB9A
SCHEMBL7490131 0.87 PTGIR (0.69) PTGER4PTGIRPTGER1PTGER3TDP1
SCHEMBL8548330 0.86 PTGIR (0.64) PTGER4PTGIRPTGER1PTGER3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0842161-B1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO (JP) 2002-09-18 EP disclosed
EP-1213285-A2 4,5-dipheny-oxazole derivatives and their use as platelet aggregation inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-06-12 EP disclosed
US-6300344-B1 FOR THERAPEUTIC AND/OR PROPHYLACTIC TREATMENT OF ARTERIAL OBSTRUCTION, CEREBROVASCULAR DISEASE, HEPATIC CIRRHOSIS, ARTERIOSCLEROSIS, ISCHEMIC HEART DISEASE, RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY, HYPERTENSION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-10-09 US disclosed
US-5972965-A USEFUL FOR INHIBITION OF PLATELET AGGREGATION, VASODILATION, ANTIHYPERTENSIVE ACTIVITY AND PROSTAGLANDIN AGONIST FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-26 US disclosed
EP-0842161-A1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-05-20 EP disclosed
WO-1997003973-A1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-02-06 WO disclosed