Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL747272 | 0.79 | PIK3CA (0.41) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL747739 | 0.71 | PIK3CD (0.38) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL2671996 | 0.71 | MTOR (0.42) | LRRK2PIK3CDMTORBRD4AXL | |
| SCHEMBL746345 | 0.68 | PRKCZ (0.43) | PIK3CDMTORBRD4AXLCDK8 | |
| SCHEMBL2672158 | 0.67 | MTOR (0.41) | CHRNA7LRRK2PIK3CDMTORBRD4 | |
| SCHEMBL2672618 | 0.67 | CDK8 (0.45) | LRRK2PIK3CDMTORBRD4AXL | |
| SCHEMBL743968 | 0.66 | CHRNA7 (0.53) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL743970 | 0.66 | PRKCZ (0.46) | PIK3CDBRD4AXLCDK8PIK3CA | |
| SCHEMBL18857740 | 0.66 | CHRNA7 (0.65) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3390939 | 0.66 | CHRNA7 (0.65) | CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431368-A1 | CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives | Abbott Laboratories (US) | 2012-03-21 | — | — | EP | disclosed |