Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.65 |
| ▸ | MITF | O75030 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | FABP4 | P15090 | 1/20 | 0.57 |
| ▸ | MYC | P01106 | 1/20 | 0.57 |
| ▸ | MAX | P61244 | 1/20 | 0.57 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490262 | 1.00 | CISD1 (0.65) | CISD1MAOAMAPTNCOA3MITF | |
| SCHEMBL7493574 | 0.97 | CISD1 (0.64) | CISD1MAOAMAPTNCOA3MITF | |
| SCHEMBL7493581 | 0.97 | CISD1 (0.64) | CISD1MAOAMAPTNCOA3MITF | |
| SCHEMBL7491497 | 0.95 | FFAR1 (0.67) | CISD1MAOAMAPTNCOA3MITF | |
| SCHEMBL7491489 | 0.95 | FFAR1 (0.67) | CISD1MAOAMAPTNCOA3MITF | |
| SCHEMBL7487007 | 0.92 | FFAR1 (0.66) | CISD1MAOAMAPTNCOA3MITF | |
| SCHEMBL7487001 | 0.92 | FFAR1 (0.66) | CISD1MAOAMAPTNCOA3MITF | |
| SCHEMBL6885016 | 0.90 | PTPN12 (0.64) | KMT2AAKR1B1PTPN1 | |
| SCHEMBL6885013 | 0.90 | PTPN12 (0.64) | KMT2AAKR1B1PTPN1 | |
| SCHEMBL12008482 | 0.89 | CISD1 (0.71) | CISD1MAOAMAPTNCOA3MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192143-A1 | RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | claimed |
| WO-2000076987-A1 | RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2000-12-21 | — | — | WO | claimed |
| EP-1192143-A1 | RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076987-A1 | RHODANINE DERIVATIVES FOR USE IN A METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |