Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | KDR | P35968 | 3/20 | 0.64 |
| ▸ | AXL | P30530 | 2/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060866 | 1.00 | EGFR (0.72) | EGFRPDGFRAPDGFRBKDRAXL | |
| SCHEMBL5824865 | 0.88 | PDGFRA (0.61) | EGFRPDGFRAPDGFRBKDRAXL | |
| SCHEMBL7481076 | 0.87 | EGFR (0.78) | EGFRPDGFRAPDGFRBFGFR2 | |
| SCHEMBL19373176 | 0.85 | EGFR (0.74) | EGFRPDGFRAPDGFRBKDRFGFR2 | |
| SCHEMBL31061546 | 0.85 | EGFR (0.74) | EGFRPDGFRAPDGFRBKDRFGFR2 | |
| SCHEMBL17117826 | 0.84 | FGFR2 (0.78) | EGFRPDGFRAPDGFRBKDRKIT | |
| SCHEMBL31060325 | 0.84 | FGFR2 (0.78) | EGFRPDGFRAPDGFRBKDRKIT | |
| SCHEMBL31060617 | 0.84 | EGFR (1.00) | EGFRPDGFRAPDGFRBKDRFGFR2 | |
| SCHEMBL7478985 | 0.84 | EGFR (0.72) | EGFRPDGFRAPDGFRBKDRFGFR2 | |
| SCHEMBL6431286 | 0.84 | EGFR (0.72) | EGFRPDGFRAPDGFRBKDRFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | claimed |
| EP-0860433-B1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BREWERY (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-6143764-A | ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2000-11-07 | — | — | US | disclosed |
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | disclosed |