Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 4/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17241522 | 0.88 | HTT (0.50) | HTTTSHRDHODHMALT1RXFP1 | |
| SCHEMBL25311292 | 0.88 | DHODH (0.43) | HTTTSHRDHODHRXFP1MEN1 | |
| SCHEMBL529214 | 0.86 | HTT (0.63) | HTTTSHRDHODHMALT1RXFP1 | |
| SCHEMBL2725311 | 0.86 | HTT (0.49) | HTTTSHRDHODHMALT1RXFP1 | |
| Hydrochloric Acid SCHEMBL25311682 | 0.86 | DHODH (0.42) | HTTTSHRDHODHRXFP1MEN1 | |
| SCHEMBL2721434 | 0.84 | LMNA (0.58) | TSHRDHODHMEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL9872122 | 0.83 | LMNA (0.60) | TSHRDHODHMEN1KMT2ALMNA | |
| SCHEMBL741418 | 0.83 | HTT (0.55) | HTTTSHRDHODHRXFP1MEN1 | |
| SCHEMBL403348 | 0.82 | TSHR (0.66) | HTTTSHRMALT1RXFP1KDM4E | |
| SCHEMBL10282056 | 0.82 | HTT (0.49) | HTTTSHRDHODHMALT1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106255692-A | Imidazo [4,5-c ] quinolin-2-one compounds and their use in treating cancer | 阿斯利康(瑞典)有限公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-105859684-A | Fused ring compound and preparation method, application and intermediate compound thereof | 四川赛诺唯新生物技术有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103476755-B | Compounds and methods for | CLANOTECH AB (SE) | 2015-08-26 | — | — | CN | disclosed |
| CN-103044446-A | Heterocycle quinoline derivatives as well as medicinal salts, preparation method and medicinal application thereof | SHANGHAI HENGRUI PHARM CO LTD | 2013-04-17 | — | — | CN | disclosed |
| WO-2008119771-A2 | QUINOLINE-S-CARBOXYLIC ACID DERIVATIVES AS TYROSINE KINASE INHIBITORS | CLANOTECH AB (SE) | 2008-10-09 | — | — | WO | disclosed |
| CN-1097459-C | Diazepino-indoles as phosphodiesterase IV inhibitors | JOUVEINAL INST RECH (FR) | 2003-01-01 | — | — | CN | disclosed |
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |
| CN-1160352-A | Diaza * -oxindoles as phosphodiesterase IV inhibitors | JOUVEINAL INST RECH (FR) | 1997-09-24 | — | — | CN | disclosed |
| EP-0785789-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (I.R.J) (FR) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011690-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1996-04-25 | — | — | WO | disclosed |