Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490406 | 1.00 | ESR1 (0.67) | ESR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL25197132 | 0.92 | HDAC3 (0.79) | ESR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18694423 | 0.88 | HDAC3 (0.61) | ESR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18694425 | 0.88 | HDAC3 (0.61) | ESR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3217272 | 0.86 | HDAC3 (0.67) | ESR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3217238 | 0.86 | HDAC3 (0.67) | ESR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7452784 | 0.85 | PTGS2 (0.77) | ESR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7452771 | 0.85 | PTGS2 (0.77) | ESR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1483235 | 0.82 | HDAC3 (0.54) | ESR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1483233 | 0.82 | HDAC3 (0.54) | ESR1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912567-B1 | CARBOLINE DERIVATIVES | ICOS CORP (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6306870-B1 | PHOSPHODIESTERASE ENZYME INHIBITORS, CARDIOVASCULAR DISORDERS AND SEXUAL DISORDERS | ICOS CORPORATION | 2001-10-23 | — | — | US | disclosed |
| US-6117881-A | POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE | ICOS CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| US-6043252-A | A POTENT AND SELECTIVE INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE (CGMP-SPECIFIC PDE); TREATING CARDIOVASCULAR DISORDERS AND ERECTILE DYSFUNCTION | ICOS CORPORATION (US) | 2000-03-28 | — | — | US | disclosed |